This article first elaborates on the universal rule of Manufacturing structure upgrading. And then，uses empirical methods to measure the degree of Guangzhou Manufacturing industry upgrading，and proves there was a huge change in the industrial structure under manufacturing sector in Guangzhou since the early 21st century。The manufacturing Strulture Changes from previous labor-intensive industries to high-intensive，high processing，high-tech industry ；the proportion of advanced manufacturing and high-tech industries inaeases steadily. Development of the manufacturing industry can be segmented into several stages，the paper analyzes Guangzhou manufacturing industry gradually advanced process within the same stage and different stages.