This article makes the develop strategy of Guangzhou Development District cultural industry，by analyzing the external environment and market demand of cultural industry in Guangzhou Development District，under the guide of features of Guangzhou Development District cultural industry. The develop strategy of Guangzhou Development District is taking the industry characteristics of Guangzhou Development District as a strategy planning，following the principle of discrepant development and misalign development，aiming to strengthening comprehensive competitiveness，and allocating plans according to the cultural industry definition standers in China，competitive advantages of Guangzhou Development District，and the strategy of creating new competitive advantages in the base of traditional advantages.