Guangzhou has been the innovative pilot city selected by the Ministry of Science and Technology and National Development and Reform Commission，whose innovative building effect would influence the process of the implementation of innovative nation strategy in China. Beginning from the connotation，definition，evolution and classification of innovative city，the paper reviews the innovative city practice in London，Singapore，etc，concludes the objective settings of main domestic innovative city like Beijing，Shenzhen，etc，analyzes the advantages，process and shortcomings of Guangzhou in building national innovative city，and sets the objectives for Guangzhou in building the national innovative city. The proposals are also offered in followings：optimizing the Guangzhou innovative atmosphere，taking great effort in developing human resources，establishing the enterprises as the leading role in innovative city building，accelerating the innovative industries clustering development，exploring and developing the technology property right trade and strengthening the regional cooperation.