Stimulating the innovative resources vigor is the key to improve the independent innovation capability，which determines a city，a region and a nation’s independent innovation capability. During the 12th Five-year-plan，Guangzhou should take the advantage of being the national innovative pilot city，improves its independent innovation capability significantly，adopts the measures of establishing “industry-university-research-application” innovation alliance，implementing intellectual property rights strategy，constructing diversified public service network and regional innovation cooperation system. Besides，Guangzhou also need to strengthen the clustering of innovative resources，especially for the high level innovative resources，stimulate the diversified innovation bodies’ vigor leading by enterprises，and accelerate the construction pace of national innovative city and South China science and technology innovation center.