Improving Guangzhou’s independent innovation capability is of great significance to Guangzhou in building national innovative city of scientific innovation thinking，innovation main body standing out，innovation vigor spring up，innovative system well developed，innovative talents bringing up，innovation institution well established，large scope of innovation radiation and strong in innovation role leading，and to the improvement of Guangzhou city development mode，as well as to the acceleration of national central city construction. The main effective measures are：impelling the Guangzhou core technology innovation，strengthening the independent innovation main body position，constructing regional innovation system，improving the intellectual property rights institutions，talents resources integration，optimizing the independent innovation atmosphere and learning experiences from advanced cities.