This paper analyzes the basic route for Guangzhou Development District's structural adjustment, transformation and upgrading: a) optimize the environment and create a new platform for transformation and upgrading, b) improve the manufacturing and make a new engine for industry cluster, c) push the creation and make a highland for knowledge-based economy, d) expand the service and create a gathering place for high-end services, e) Carry out green development and set a new example of low-carbon economy. <<