To promote the sustainable development of small and medium-sized industrial enterprises is an important topic，also is an essential way for that adjustment of economic structure，improve the quality and efficiency of economic development，and promote national economic sustainable development.This paper analyses present situation of small and medium-sized industrial enterprises，position and function and existing problems of small and medium-sized industrial enterprises by using the date of The Guangzhou Second Nation Economic Census，this paper puts forward some suggestions for the development orientation also.