The total of 425 university students from first grade to forth grade in Guangzhou are recruited in this research. Using self-report questionnaires，data reflecting subjective well-being are collected. Gender difference and the difference between rural and urban students are compared. The relationships among family socioeconomic status，personality traits，perceived social support and subjective well-being are examined by structural equation modeling. The results show that SES affected subjective well-being through perceived social support. Moreover，based on the result，a framework about improving individual’s subjective well-being in social work practice is discussed.