This paper implements a comparative analysis of the major Over-the-Counter（OTC）Markets（USA NASDAQ market，Japanese JASDAQ market，Taiwan Emerging Equity Markets）and a historical analysis of development of China’s over-the-counter（OTC）equity market. The study discovers the macro-contour for major international OTC markets. Then according to the history，society and economic environment of Tianjin，constructing Tianjin’s OTC market，as a key layer market of multi-layer market，which meets the demand of the market economy，needs to draw lessons from NASDAQ etc. The paper explores a comprehensive idea for construction of OTC market and finally analyzes three feasible solutions.