In order to promote the sustainable development of science and technology association institutions，establish benign operation mechanism，Guangzhou Association for Science and Technology and Guangzhou Academy of Social Sciences jointly carry out the research on the development of the institutions of Guangzhou Association for Science and Technology.This research comprehensively and systematically investigates the development status and problems of Guangzhou Association for Science and Technology，and clear the main direction of reform and development in the future. The paper proposes that play Institutions’ positive role in regional economic and social public welfare.