With the rapid development of our economy and the continuously improvement of the standard of living，human health is the one of the primary concern and drug safety issue has been the social focus. Currently，Drug safety is raised to the national strategy. How to ensure the drug safety and optimize drug administration has been the most important subjects to build service government，construct a harmonious society and hold to the mass line of the party. The article illustrates how Beijing Tongzhou Food and Drug Administration explores the drug administration license and supervision. Tongzhou Food and Drug Administration preliminary establish “the rights of Approval，enforcement and supervision”. The work mechanism is that the three powers are separated and connected with each and restricting each other. It is a helpful exploration to construct the honest and clean government and the three powers are separated and connected with each and restricting each other to form the closed loop of honest and clean government supervision system.