There are some reasons for the vigorous development of regional police cooperation：the economic and social development running deep，the demonstration effect of cooperation practice，the security requirement of center city and police cooperation experience of international and regional.At present，free and unconditional for cooperation，local protectionism and lack of responsibility mechanism and so on，are the main factors to hinder the further development of regional police cooperation.It is necessary to build standard system of regional police cooperation，continue to promote the construction of police cooperation zone and “point” to “point” cooperation for intensive areas，establish benefit compensation mechanism，incentive mechanism，effective supervision mechanism，accountability mechanism and dispute resolution mechanism of regional police cooperation to constantly improve the regional police cooperation.