In the past 5 years，the status of sci-tech innovation in Guangzhou experienced a significant transformation process. Under the guideline of the national sci-tech development strategy，especially the concept of scientific development，Guangzhou promoted the status of sci-tech innovation in the city’s development gradually，city’s development objectives become increasingly clearer and accurate. CPC Guangzhou Municipal Committee and Guangzhou Municipal Government fully realized the government’s function in responsible for promoting sci-tech innovation，and made efforts to optimize and improve the policy and legal climates for sci-tech innovation and high-tech industry development，and much has been accomplished in this regard. Guangzhou should further develop the sci-tech innovation’s significant role in propelling economic and social development，and realize the development goals of innovative city and the construction of “leading area” of the province earlier.