Enterprises often confront difficulties in financing，especially for sci-tech enterprises. It is a problem that troubles the nation’s and cities’ development for years. The state and communities have given much concern about this issue and propose many constructive suggestions. Guangzhou should adapt to needs of economic development and establish sci-tech bank as soon as possible，based on Guangzhou’s characteristic，city’s orientation and advantages，which is be of great significance to Guangzhou’s construction of regional finance center，“leading area” of the province and modern services industry system.