The development and application of Guangzhou Asian Games Sci-tech is a great system engineering，which is directly related to key technology in hosting Guangzhou Asian Games successfully. High-tech Asian Games is also a special sci-tech and social development strategy，and a special sci-tech development mode within a period of time. Its development and application successfully will be of great significance to Guangzhou’s sci-tech innovation and high-tech industry development. This paper studies the objectives and principles of Asian Games sci-tech development，and probes its application fields，analyzes its leading role on high-tech industry and proposes guarantee measures on developing Asian Games sci-tech well.