It is not sufficient that a region，a unit，an organization only has talents. The most important things are making good use of these talents and giving full play to their intelligence and ability in order to make great contribution to the development of society and the advancement of human being. This article proposed the concept of use benefit of talents resources. It has constructed economic efficiency evaluation model of the regional talents use to appraise and compare use benefit of regional and industrial professional technical talents in China，and obtained meaningful research results.