In 2003 SARS epidemic in China，in order to inform society of the epidemic timely，ensure social stability，Ministry of Health spokesman Mao Qun’an on behalf of the health sector started to face the social masses actively，communicate with the public，so as to guide the public opinion. This essay used methods of qualitative analysis and quantitative analysis，theories of discourse and the agenda-setting. It mainly analised the discourse characteristics of Mao Qun’an facing the media，as well as the effect to defuse the crisis by agenda setting and the mechanism of building the image of government. As the spokesman of the Ministry of Health，the long-term work of Mao Qun’an，provided experience for the future news spokesman in the face of health events.