To this article，whether from the comprehensive strength and technological resources conditions，or the slowdown in economic growth，Guangdong have to turning the innovation model from imitation to original innovation. Guangdong should break down the misunderstanding in original innovation and do not depend the imitation again，original innovation must be the core strategy in now and future. And we must make sure to build Guangzhou as the new “science and technology innovation point” from the basic investment protection，talent team construction，collaborative innovation platform construction，and consulting research strategy.