Based on analysis in London，Mexico City，and Singapore，this research examines international experiences in dealing with urban diseases . Urban diseases are negative effects of unbalanced development. Foreign practices have proven that that urban diseases can be cured whentaking appropriate and persisiting measures，and it will be more effective if comprehensive approaches are applied，including political，economic，cultural，technological，legal，and administrative measures. It is key to establish a treatment and prevention mechanism against urban diseases，the core of which is to enhance social force and to remediate market forces. Domestic big cities are currently threathened by high morbidity of urban diseases. It is better for them to bring in sound and advanced international experiences and take effective measures to combat urban diseases.