The third industrial revolution caused by new technological revolution is now leading to the reconstruction of the global industrial system，and promoting a new round of global competition of science and technology innovation. From the global technology innovation network system，the vigor of innovation comes mainly from several functional nods in global city network. Inside global cities，cluster of innovation resources have become a general trend，and have formed a number of different innovation cluster models. Facing the new situation，the central government demand Shanghai to accelerate the innovation of science and technology. Which requires Shanghai to face the international background，to draw experiences from developed countries，to aim at the restrictive factors existing at present，and actively explore a development road driven by innovation.