Based on resources and existing industries，in the Yangtze River Delta，cities become more professional and larger scale. According to the opportunity of the new science and technology revolution trend，the fundamental research and strategic high technology research become further strengthen，the factors of regional knowledge，information，personnel and others had been allocated and used reasonable，and the level of the regional integration Science and Technology innovation is increasing by a large margin. Now，how to grasp the new situation，break through the bottleneck，promote the whole competitiveness of the Yangtze River Delta ascension，is the key starting points and focus to the next step development.