Innovation is homologous with creative while S&T keeps closing connection with culture. On one hand，S&T puts vitality and power into culture and on the other culture gives inspiration and rooms for technology. They merge with each other in the every stage from the production to consumption of any creative goods. Recently，Shanghai creative industry grows rapidly and has made a lot of progress on the value increasing，category classification，enterprise agglomeration，park distribution，policy making and so on so forth. Nevertheless，the mechanism of the merging is far from satisfactory and most creative industry parks still rely on land rent income but not innovation. There are lots of success examples in the world to illustrate the importance and how to promote the merging to exert the effects of S&T having on the creative industry by Silicon Valley，London creative workhouse and Taiwan. It is concluded that such merging between S&T and culture needs more open atmosphere，larger cluster of SME，whole-industry-chain profit model，crossover interdisciplinary talents and public service systems.