The Negative-List management mode reform in China（Shanghai）experimental Free-Trade Zone demands the government to deal with the relationship between government and market，utmost ground vacates the market space and stimulate the vitality of enterprises. Therefore，the government must further the reform of administrative examination and approval system，and form a set of management and control of market risk，safeguard market order system. In this paper，through the interpretation of the Negative-List management mode，clarifies the basic connotation and the core concept，analysis of the influence of Negative-List management mode of the administrative examination and approval system. Based on the summary of Pudong New Area’s six round of administrative examination and approval system reform practice，we will put forward some prospective reform ideas.