There is a diverse cultural resources in Guizhou province with many races and mountains，which have many unique and distinct advantages in culture. So，to use the soft power advantages of culture to achieve the goal of strong province，it must find advantages of Guizhou culture and avoid the disadvantages，and measure the culture with scientific methods and systems. Therefore，it is very important to study and develop the index system of strong culture province in Guizhou province. With the concept of powerful cultural country put forward on the eighteenth congress as the policy basis，this report studies the development of index system of strong cultural province in Guizhou，combined with the actual development of Guizhou culture.