As the national centre city，with the Wuhan-Guangzhou，Nanning-Guangzhou，Guizhou-Guangzhou，Shanghai-Shenzhen high-speed rail running，the impact of Guangzhou in the area of Pan Pearl River Delta and high-speed rail economic zone is much deeper than ever. To further enhance the radiation capacity of Guangzhou，the government should not only be conducive to broaden the development of the hinterland of Guangzhou，strengthen economic ties，and to form win-win cooperation structure，but also strengthen the role of Guangzhou in our national center status. Based on the analysis the radiation capacity of Guangzhou，the elements gathering and configuration，manufacturing radiation，radiation services，logistics radiation，radiation and other basic aspects of innovative features，this paper evaluates city’s own radiation capacity，channel system construction of urban and hinterland，and cooperation of urban and hinterland，finds out the main idea and gives suggestions about how to enhance Guangzhou radiation capacity. <<