In the Euro-Asia region along “The Belt and Road”，Shanghai has geographical advantages，institutional innovation advantages，and advantages of talent aggregation and scientific and technological innovation. In the future，Shanghai can become the biggest city cluster，service center，and scientific and technological innovation center of “the Belt and Road” areas. In order to help Shanghai to cope with the challenges brought by the problems concerning regional security，resources，and adjustment of industrial structure，we propose the following measures：Shanghai should take an effort to build a regularized regional security system in collaboration with Chinese provinces and foreign countries along “the Belt and Road”，construct an inherent system that integrates various types of resources，and prioritize some specific categories and fields of its economy as key industries and sectors for Shanghai’s industrial development.