At present，the economic construction of China enters development phase of “13th-Five-Year Plan”. Under the national strategic backdrop of implementing “the Belt and Road” and “Yangtze River Economic Zone”，demands of Shanghai International Finance Center construction and reform with development in Shanghai Free Trade Zone，and strategic goal that building “global city” proposed by a new round of Shanghai urban comprehensive plan，the development of Shanghai CBD ushers in new opportunities and challenges. Based on regional perspective，this paper systematically teases the development history of Shanghai CBD from industrial and spatial angle，deeply analyzing the influence of Shanghai CBD on regional economic development of Yangtze River Delta，and proposing countermeasures and suggestions about CBD construction promoting economic integrated development of Yangtze River Delta. <<