The Gross Domestic Product of Guangzhou ranked third in China，but the economic competitiveness index ranked ninth and the innovation force is fifth. If things go on like this，economic growth will be bogged down. The Therefore，Considering the economic and social development reality of Guangzhou，we adopted the perspective of the theory of Polycentric governance，and suggested further construction of innovation environment，improve cooperation in science and technology innovation system and strengthening the team construction of innovative talents.