In recent years，private enterprises had become an important part of national economy in Guangzhou and played a dominant role in technological innovation，as well as made great contributions to Guangzhou economic and social development. At present，Chinese economic development has entered a “New Normal” and shows a series of trend changes. With this background，in order to remain invincible in the fierce market competition，technological innovation is one of the most difficult and most important tasks faced by Guangzhou private enterprises. According to the analysis of current situation and existing problems of Guangzhou private enterprises science and technology innovation，the group tries to propose the suggestions to accelerating the improvement of science and technology innovation and incentive system in Guangzhou private enterprises.