As a new business type and commercial model，e-commerce is under rapid development. It is quickly penetrating into every social and economic field，and has become an important power source and growth point for the development of business and commercial industry. Using a large number of detailed and accurate on-line sales statistics，combining in-depth interview with key research results，the paper deeply analyzed and comprehensively concluded the overall development situation，spatial layout，development situation of major platforms，main characteristics and problems in Guangzhou’s e-commerce of recent years. The paper also put forward countermeasures and suggestions for further accelerating the healthy and rapid development of e-commerce and advancing the deeper integration of e-commerce and the real economy.