Steady growth of Guangzhou manufacturing made an important contribution of total amount and structure adjustment to the status of “World Manufacturing Center”. However，the amount and quality of manufacturing should be improved，and the pillar industry is less and faces change and turnover. The spatial links of industry need to be strengthened，the ecosystem should also be improved. Besides，the cost increased and the export capacity called for improvement. Guangzhou faced unprecedented，all-round and multi-level competition. Therefore，the innovative development of Guangzhou manufacturing has to establish five strategies：stock enhance，increments improvement；spatial links，emphasis on inside and outside and ecosystem. The strategic position of the manufacturing need to be correctly understood to take comprehensive measures to enhance the competitiveness of the manufacturing.