Informatization of science popularization is in nature the completely mediated course for science communication induced by the information and communication technologies （Acts）. The institutionalization in technology，culture and society opens up a broad space for public service，social support and mass communication. The development of the Acts provides a convenient path for content production，information spreading，public engagement and interagency collaboration in science communication. New types of information forms，knowledge connections and public’s activities within informatizational context require a full utilization of Acts in science communication to address the challenge of the very different demands，behaviors and rules in the Internet age. Informatization thus not only brings a new action arena for science communication，but provides diverse approaches for science popularization. We investigated a number of exemplified practice cases advanced by different base units of the Associations for Science and Technology （AST） in various regions. Several typical practice models were concluded from these cases and long-term strategy mechanisms for sustainable development of Informatizational science popularization are proposed.