“The Belt and Road” initiative is a strategy launched by Chinese government for opening up in the new era，which focuses on the communication in policy，infrastructure，trade，capital and person in the region. “The Belt and Road” initiative will bring Shanghai an important development opportunity because of its special location advantage and the first mover advantage in Chinese reform and opening up. Based on its position in city function and its existent advantages，serving the national strategy，Shanghai should treasure the opportunity to participate in the regional communication and cooperation promoted by “the Belt and Road” initiative and try to make win-win deals for all partners.