The downside risk for China’s economy keeps rising in recent years amid the global recession and diminishing on investment-driven development model. Therefore，The Silk Road Economic Belt and the 21st-century Maritime Silk Road，also known as “the Belt and Road”，has become the top strategy of Chinese government. Shanghai and Hong Kong，as two of the 18 core participating cities and provinces in China，have their unique competitive edge. Shanghai has relative strong industrial system and environment for technology innovation while Hong Kong’s legal system and human capital make it one of the international financial centers. Cooperation between Shanghai and Hong Kong creates considerable synergy effect and business opportunities that not only benefit the cities but also help China to achieve the “One Belt，One Road” policy aims.