In recent years，Yangtze River Economic Belt plays an increasingly important role in entrepreneurship and innovation development throughout China. As the core of Chinese entrepreneurship territory，Yangtze River Economic Belt provides a convenient platform and abundant resources for the industrial amalgamation of start-ups. Nonetheless，plenty of bottlenecks still exists，such as difficulty of financing，shortage of talents and defects of policy systems，therefore hindering the sustainable development of start-ups. Currently，the focus of promoting national innovation lies in the improvement of social service system，as well as the broadening of financial channels for small business.