Life stress is a condition or feeling of strain and pressure，which experienced when a person perceives that demands exceed the personal and social resources the individual is able to mobilize. Based on the analysis of data from CASS-KDnet Social Mentality Survey 2016，this report revealed the scores of life stress including economic and interpersonal stressors. It showed the serious extent of life stress among four types of cities，especially second-tier and third-tier cities，and among Yangtze River Delta metropolitan area，Beijing-Tianjin-Hebei metropolitan area，Pearl River Delta metropolitan area.