There are three key issues in global macroeconomy and financial markets in 2016，namely the normalization of the Fed monetary policy，the widening and deepening of the negative interest rate policy，and the UK’s vote to leave the EU. One common feature of these issues is that huge uncertainties hover above their related policy practice and impact，due to a lack of historical precedents. Against this background，global think-tanks and academia made heated discussions around these issues. The paper introduces and comments the contents，opinions，divergences and policy implications of these issues.