As an important part of the central China and the Yangtze River Economic Zone，the finishing building a moderately prosperous society in all respects of Changjiang Middle Reaches Megalopolis has a far-reaching significance to economic and social progress and the finishing building of a moderately prosperous society in all respects for the central China，even the whole country. This paper analyzes the basis of a well-off society in an all-round way for Changjiang Middle Reaches Megalopolis，and new challenges，new opportunities，new challenges. Then，to adapt to the the new normal of economic growth，we put forward the major tasks and policy support of finishing building a moderately prosperous society in all respects for Changjiang Middle Reaches Megalopolis.