The research shows that poverty of the disabled in the minority-concentrated region has four characteristics：overlapping poverty level，overlapping vulnerability，overlapping human capital vulnerability and overlapping poverty culture. The complexity of poverty-alleviation development for the disabled in region is reflected by that failure of poverty-alleviation policiesfor the disabled in the region，more constraints and arduous tasks；that the disabled has poor personal conditions，with high poverty-alleviation difficulties. Generally speaking，improvement of the effect of anti-poverty for the disabled in the region can be boosted from the following four aspects：1.Establishing the poverty-alleviation management system with “poverty-alleviation office as the competent department and the Disabled Persons’ Federation and the Nationalities Affairs Commission as the auxiliary departments”；2. Guarantee comes first，development follows；3. Taking housing and environmental improvement as the top priority in poverty alleviation in the region；4. Implementing HR lifting plan for the disabled in the region.