Opening to the outside world after the reform and opening up has played an important role in the Shanghai science and technology innovation development, Shanghai science and technology in 30 years opening to the outside world has experienced exploration stages of infancy, rapid advance and comprehensively deepen, the form of opening to the outside world also gradually by the "introduction" to "go out", especially through the capital cooperation to promote foreign science and technology innovation cooperation, have produced a variety of successful opening mode of science and technology.Under the background of cafta construction in Shanghai, Shanghai science and technology in the form of opening to the outside world more diversification, this trend also requires flexible policy to further open, to give more support to the scientific and technological innovation.