Global innovation networks（GINs）is coming from globalization of knowledge，science and technology，and it is more complicated than global production networks. Global innovation networks include knowledge innovation network which focus on knowledge source，start-up service network which focus on transformation of S&T achievements，and commercialization network upgrading from GPNs. Among them，knowledge innovation network is the base layer and knowledge source for GINs，which is mainly composed of publications，academic conferences，cooperative researches and overseas study activities. This paper choose journals published by Science Citation Index（SCI）as study object to reveal spatial layout of global knowledge innovation network structure and spatial pattern，and deepen the study for global innovation networks and its node connotation. Finally，the paper puts forward innovation inspirations for cities in China.