Under the background of The Belt and Road strategy，Guangzhou proposed to building an international shipping center relied on the seaport and the air port，one of the key element of the target is perfecting the hub collection and distribution system. This article through the analysis of the status and problems of the hub collection and distribution system，defined the demand characteristics and development trends of which. On this base，the article has researched the basic idea of suggestions on optimization the hub collection and distribution system of Guangzhou international shipping center and propose some related countermeasures. The researches can provide a reference for the government of Guangzhou and other cities.